Thyroid cancer is one of the most common malignant tumors in endocrine system with a growing incidence that accounts for 1% of the total malignant tumors. Pax-8-PPARG gene fusion results in the production of a Pax-8-PPAR-γ fusion protein(PPFP), which is found in approximately 30% of follicular thyroid carcinomas(FTC). Both human and animal research findings indicate that PPFP acts as an oncoprotein, though the specific mechanism remains unclear at this time. PPFP is considered to be a dominant-negative inhibitor of wild-type PPAR-γ or a unique transcriptional activator of PPAR-γ genes.
With the benefits of intuitive results, stability, simple operation, rich sample sources, etc., fluorescent in situ hybridization(FISH), through detection of PPAR-γ genes, can assist in clinic in diagnosis and prognosis prediction for cases whose cytology results cannot be determined.
PAX8-PPARG Fusion/Translocation FISH Probe Kit