DNA chimera STR & virus infection monitoring after HSCT

         Hematopoietic stem cell transplantation(HSCT) is the transplantation of allogeneic or autogeneic hematopoietic stem cells into the recipient for the reconstitution of hematopoietic functions and immune functions to treat certain diseases. Dynamic monitoring of DNA chimera and post-transplantation virus infection, etc. for HSCT patients can effectively reduce the incidence of graft-versus-host diseases and improve the quality of life of the patients.

        1. Post-transplantation dynamic monitoring of chimerism is particularly important for evaluating the outcome of transplantation and performing early clinical intervention. Fluorescently labeled multiplex PCR amplification of STR loci, combined with  automated capillary electrophoresis method, is highly sensitive, reproducible, simple and efficient and has become the IBMTR-recommended “gold standard” for the detection of donor-recipient chimerism.

STR detection kit

         2. Virus infection is one of the most common complications in post-transplantation patients and is often the major cause of transplantation failure. BKV, JCV, HCMV and EBV are ubiquitous and in a latent state; transplantation patients using immunosuppressant have low immunity and are prone to virus infection. Therefore, post-transplantation virus monitoring is an important means of ensuring successful transplantation.

Virus infection detection kit